Kindling 5

Kindling 5 PDF

Author: Michael E. Corcoran

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 507

ISBN-13: 146155375X

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The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

Kindling 6

Kindling 6 PDF

Author: Michael E. Corcoran

Publisher: Springer Science & Business Media

Published: 2007-12-05

Total Pages: 416

ISBN-13: 0387261443

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Proceedings of the Sixth International Conference on Kindling, featuring valuable summaries of the participants’ current cutting-edge research on the kindling of seizures and related phenomena in epilepsy.

Kindling 4

Kindling 4 PDF

Author: Juhn A. Wada

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 471

ISBN-13: 1468457969

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This is the proceedings of the fourth in a series of inter national gatherings on kindling held on the University of British Columbia campus, June 15-17, 1989. Since the last gath ering in 1985, kindling continues to attract an ever-increasing number of investigators as reflected by the phenomenal increase in the number of kindling-related research reports. No other acute or chronic model has been exploited so extensively using electrophysiological, pharmacological, biochemical and behav ioural approaches involving a variety of brain sites and ani mal species. The continuing search, during the past few years, for the mechanism underlying the enduring change induced by kindling is beginning to shed some light on aspects of its molecular basis and to suggest the future direction of research. The late Graham Goddard, the original kindler, would have been delighted with this development. We were all shocked and saddened by his tragic death, but his spirit is very much alive among all of us who gathered together to share new information and collectively reassess the present state of knowledge at this symposium. I must say that we miss him very, very much. We know he is happy in his heaven knowing that he accomplished more in a short lifetime than most and that his love for mankind, and life's challenges, remain as a legacy, and goal, for us all.

Intractable Seizures

Intractable Seizures PDF

Author: W. McIntyre Burnham

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 252

ISBN-13: 1461513359

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About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.