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Small Doses

Author: Amanda Seales

Publisher: Abrams

Published: 2019-10-22

Total Pages: 435

ISBN-13: 168335494X

This “one-of-a-kind read” offers insightful essays, poignant life advice, and pithy pearls of wisdom from the comedian and star of HBO’s Insecure (Entertainment Weekly). Anyone who has seen Amanda Seales’s acclaimed stand-up special I Be Knowin, her long-running TV series Insecure, or her groundbreaking gameshow Smart Funny & Black, knows that this woman is a force of nature. In both life and career, she has fearlessly and passionately charted her own course. Now she’s bringing her life’s lessons and laughs to the page with her signature blend of academic intellectualism, Black American colloquialisms, and pop culture fanaticism. This volume of essays, axioms, original illustrations, and photos provides Seales’s trademark “self-help from the hip” style of commentary, fueled by ideology formed from her own victories, struggles, research, mistakes, risks, and pay-offs. Unapologetic, fiercely funny, and searingly honest, Small Doses engages, empowers, and enlightens readers on how to find their truths while still finding the funny!

The Truth in Small Doses

Author: Clifton Leaf

Publisher: Simon and Schuster

Published: 2013-07-16

Total Pages: 513

ISBN-13: 1476739986

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A decade ago Leaf, a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress-- brilliant young scientists-- are now abandoning the search for a cure.

Management in Small Doses

Author: Russell L. Ackoff

Publisher:

Published: 1986-08-19

Total Pages: 232

ISBN-13:

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Ackoff gives the reader 52 small doses of sound management thinking, delivered with characteristic Ackoff wit, humor and clarity.

Homeopathic Care for Cats and Dogs

Author: Donald Hamilton

Publisher: North Atlantic Books

Published: 1999

Total Pages: 508

ISBN-13: 9781556432958

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In this book, Dr. Hamilton carefully and clearly lays down the essential knowledge needed to use homeopathy successfully. To read this book is to prepare you to help your animal with the many day to day vicissitudes of life ... take some time, read this book carefully, and learn of one of the greatest discoveries in the history of medicine. We are fortunate to have a healer of Dr. Hamilton's stature take us on this journey.

A Really Good Day

Author: Ayelet Waldman

Publisher: Knopf

Published: 2017

Total Pages: 257

ISBN-13: 0451494091

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"In an effort to treat a debilitating mood disorder, Ayelet Waldman undertook a very private experiment, ingesting 10 micrograms of LSD every three days for a month. This is the story--by turns revealing, courageous, fascinating and funny--of her quietly psychedelic spring, her quest to understand one of our most feared drugs, and her search for a really good day"--

Low Dose Radiation

Author: Antone L. Brooks

Publisher:

Published: 2018

Total Pages: 0

ISBN-13: 9780874223545

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Chief Scientist Dr. Antone Brooks and his Low Dose Radiation Research Program team redefined the field, applying advances in instrumentation and molecular biology from the Human Genome Project and developing new technologies to examine cellular responses. Their findings were startling. At low doses, biological reactions are unique and often unrelated to those that occur at high doses. The influential linear-no-threshold model--which predicted that damage from acute exposures can be extrapolated linearly to low dose exposures--was flawed. Small doses of radiation can have an adaptive protective effect. "Hit theory," the idea that radiation only affected cells it directly traversed, yielded to "bystander theory," which hypothesizes that cells communicate with each other and a dose to one affects others surrounding it. Low Dose Radiation describes the program's development, the scientists who made it viable, and the fundamental results, highlighting lessons learned during its lifespan.

Homeopathic Care for Cats and Dogs, Revised Edition

Author: Don Hamilton, D.V.M

Publisher: North Atlantic Books

Published: 2010-09-07

Total Pages: 625

ISBN-13: 1556439350

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Most people understand homeopathy as a treatment for people, but as this book shows, our four-legged friends can benefit from it as well. First published in 1999, Homeopathic Care for Cats and Dogs quickly became a bestseller and an important resource for anyone looking for a more organic approach to caring for their cats and dogs. Using accessible language, author Don Hamilton gives readers an authoritative overview of animal homeopathy, covering history, treatment principles, homeopathic disease theory, and simple methods for using homeopathic remedies. Homeopathic Care for Cats and Dogs offers expert guidance on home care and diet, how to obtain the information needed to choose a homeopathic remedy, how to dose remedies, how to choose the potency, and when to repeat remedies if necessary. The book lists organ systems by chapter, providing concise descriptions of symptoms, including how to evaluate patients’ illnesses and when to seek veterinary care. Remedy and supplement suggestions follow disease descriptions. Each section contains the principal remedies needed for treatment. The book ends with a materia medica, which gives more comprehensive remedy information for each medicine listed in the book. This updated edition contains a new chapter on the human-animal relationship, timely information on vaccines, as well as new remedy information in every chapter.

The Collected Works of D.W. Winnicott

Author: Donald Woods Winnicott

Publisher: Oxford University Press

Published: 2017

Total Pages: 593

ISBN-13: 0190271337

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Small Clinical Trials

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-01-01

Total Pages: 222

ISBN-13: 9780309171144

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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.